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human kidney proximal tubule epithelial cell line hk  (ATCC)


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    ATCC human kidney proximal tubule epithelial cell line hk
    Human Kidney Proximal Tubule Epithelial Cell Line Hk, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 4570 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human kidney proximal tubule epithelial cell line hk/product/ATCC
    Average 99 stars, based on 4570 article reviews
    human kidney proximal tubule epithelial cell line hk - by Bioz Stars, 2026-03
    99/100 stars

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    STAP2 regulates the advancement of renal fibrosis through the HSP27-PI3K/AKT signaling pathway. After various factors lead to renal injury, the upregulation of STAP2 promotes the interaction between STAP2 and HSP27, further enhancing the phosphorylation of HSP27 and activation of the PI3K/AKT signaling pathway, which results in the loss of <t>epithelial</t> phenotype in epithelial cells, activation of fibroblasts and ultimately results in renal interstitial fibrosis
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    hk-2 human kidney proximal tubule epithelial cell line  (Korean Cell Line Bank)
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    STAP2 regulates the advancement of renal fibrosis through the HSP27-PI3K/AKT signaling pathway. After various factors lead to renal injury, the upregulation of STAP2 promotes the interaction between STAP2 and HSP27, further enhancing the phosphorylation of HSP27 and activation of the PI3K/AKT signaling pathway, which results in the loss of <t>epithelial</t> phenotype in epithelial cells, activation of fibroblasts and ultimately results in renal interstitial fibrosis
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    STAP2 regulates the advancement of renal fibrosis through the HSP27-PI3K/AKT signaling pathway. After various factors lead to renal injury, the upregulation of STAP2 promotes the interaction between STAP2 and HSP27, further enhancing the phosphorylation of HSP27 and activation of the PI3K/AKT signaling pathway, which results in the loss of epithelial phenotype in epithelial cells, activation of fibroblasts and ultimately results in renal interstitial fibrosis

    Journal: Journal of Translational Medicine

    Article Title: STAP2 promotes the progression of renal fibrosis via HSP27

    doi: 10.1186/s12967-024-05776-6

    Figure Lengend Snippet: STAP2 regulates the advancement of renal fibrosis through the HSP27-PI3K/AKT signaling pathway. After various factors lead to renal injury, the upregulation of STAP2 promotes the interaction between STAP2 and HSP27, further enhancing the phosphorylation of HSP27 and activation of the PI3K/AKT signaling pathway, which results in the loss of epithelial phenotype in epithelial cells, activation of fibroblasts and ultimately results in renal interstitial fibrosis

    Article Snippet: The China Center for Type Culture Collection (Wuhan, China) provided the normal human kidney proximal tubule epithelial cell line (HK-2), which was grown in a DMEM/F12 medium (#G4610-500ML, Servicebio, Wuhan, China) supplemented with 10% fetal bovine serum (FBS, Gibco, USA).

    Techniques: Phospho-proteomics, Activation Assay